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Botulinum Toxin Type A Botox 100 Units Powder for Injection
Cosmetic use of Botox has skyrocketed in recent years, especially since the approval of Botulinum Toxin Type A for treatment of glabellar lines. Until recently, Botox use was mainly confined to correct muscles of facial expression over the upper one-third of the face. Presently it's application ranges from correction of lines, creases and wrinkling all over the face, chin, neck, and chest, depressor anguli oris, nasolabial folds, mentalis, medial and lateral brow lifts, to lessen shadows on one's face and maintain a smooth outline of the jaw and cheeks from all directions, to dermatological applications such as localized axillary or palmar hyperhidrosis that is nonresponsive to topical or systemic treatment
Your dose, the number of injections, the site of injections, and how often you receive the medication will be determined by your condition and your response to therapy. Most people start to see an effect within a few days to 2 weeks, and the effect usually lasts 4 to 6 months.
Reconstitution and storage
Botox is stored in a freezer at or below −5°C. The package insert recommends reconstitution using sterile saline without preservative; 0.9% sodium chloride is the preferred diluent. Some investigators suggest that reconstitution with sterile saline solution with preservative (0.9% benzyl alcohol) reduces microbial contamination and provides a weak local anesthetic effect.
Botox is denatured easily by bubbling or agitation; gently inject the diluent onto the inside wall of the vial and discard the vial if a vacuum does not pull the diluent in. The final dilution of Botox is mostly a matter of personal preference; 100 units commonly are reconstituted in 1-10 ml of diluent. Theoretically, more concentrated solutions reduce reliability in delivering a specific unit dose, and more dilute solutions lead to greater diffusion of the toxin.
Once reconstituted, Botox is kept refrigerated at 2-8°C. The reconstituted Botox should be used within 4 hours. One study found no loss of activity at 6 hours but a 44% loss after 12 hours and a 70% loss with refreezing at 1-2 weeks. Other authors report no substantial loss of potency in a 10 U/1 ml reconstituted solution kept refrigerated for 1 month.
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